Metal-free oxidative isocyanides insertion with aromatic aldehydes to aroylated N-heterocycles
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چکیده
منابع مشابه
Metal-free oxidative decarbonylative coupling of aromatic aldehydes with arenes: direct access to biaryls.
A metal-free oxidative decarbonylative coupling of aromatic aldehydes with electron-rich or electron-deficient arenes to produce biaryl compounds was developed. This novel coupling was proposed to proceed via a non-chain radical homolytic aromatic substitution (HAS) type mechanism, based on the substrate scope, ortho-regioselectivity, radical trapping experiments and DFT calculation studies. Wi...
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Though the efficiency of isocyanides as strong ligands for transition metals was recognized very early, the disclosure of metal-catalyzed arylation of isocyanides has only been explored quite recently. In most of these studies, the formation of a metal/aryl complex starting from aryl iodide or bromide is followed by isocyanide insertion and trapping of the metal/imidoyl complex with various nuc...
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Despite the long history of the investigation of nucleophilic addition to metal-bound isocyanides, some important aspects of the reaction mechanism remain unclear even for the simplest systems. In this work, the addition of the sp³-N, sp²-N, and mixed sp²/sp³-N nucleophiles (i.e., HNMe₂, HN=CPh₂, and H₂N-N=CPh₂, respectively) to isocyanides C≡NR coordinated to the platinum(II) centers in the co...
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ژورنال
عنوان ژورنال: RSC Advances
سال: 2018
ISSN: 2046-2069
DOI: 10.1039/c7ra12755c